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Although the first of many GLP-1 agonists exenatide, brand Byetta was approved for type 2 diabetes in 2005, poison centers did not handle many exposure cases until several of these agents were approved for weight loss, and their popularity skyrocketed

Dauvermann MR, Lee G, Dawson N

N Engl J Med 384(12):11131124 Osaka T, Endo M, Yamakawa M, Inoue S (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system

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Endogenous levels of GHK-Cu decline with age, a phenomenon that has prompted research interest in topical and investigational injectable formulations for potential skin regeneration, wound repair, and anti-inflammatory effects